In this case, you should be able to resolve the issue by disabling exclusive mode or by booting in clean mode to identify the culprit. If this scenario is applicable to your situation, you should be able to resolve the issue by accessing the Friends List settings and disabling Automatic Volume/gain control.

In this case, you should be able to resolve the issue by disabling the automatic microphone adjustment settings. Skype is automatically adjusting the microphone – If Skype (UWP or desktop version) is configured to launch at every system startup, chances are that’s you’re the culprit responsible for the automatic microphone adjustments.